Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke

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Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke.

Diffusion-weighted MRI (DWI) is a sensitive and reliable marker of cerebral ischemia. Within minutes of an ischemic event in the brain, the microscopic motion of water molecules measured with DWI, termed the apparent diffusion coefficient (ADC), decreases within the infarcted region. However, although the change is related to cell swelling, the precise pathological mechanism remains elusive. We...

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The Course of Apparent Diffusion Coefficient Values following Perinatal Arterial Ischemic Stroke

BACKGROUND Diffusion weighted MR imaging (DWI) plays an important role in the diagnosis of perinatal arterial ischemic stroke (PAIS) during the acute phase. Its derived apparent diffusion coefficient (ADC) can be used to quantify the diffusion restriction. Aim of the current study was to identify the changes in ADC values in the acute phase following PAIS. METHODS A cohort of 36 infants with ...

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Secondary signal change and an apparent diffusion coefficient decrease of the substantia nigra after striatal infarction.

BACKGROUND AND PURPOSE Diffusion-weighted imaging can depict secondary signal change of the substantia nigra of patients with ipsilateral striatal infarction via a decrease in the apparent diffusion coefficient (ADC). Clinical predictors of this phenomenon remain unclear. METHODS We assessed 98 stroke patients with acute ischemic lesions in the hemilateral basal ganglia, external capsule, or ...

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Relationship between apparent diffusion coefficient and subsequent hemorrhagic transformation following acute ischemic stroke.

BACKGROUND AND PURPOSE A method for identifying patients at increased risk for developing secondary hemorrhagic transformation (HT) after acute ischemic stroke could be of significant value, particularly in patients being considered for thrombolytic therapy. We hypothesized that diffusion-weighted MRI might aid in the identification of such patients. METHODS We retrospectively analyzed 17 pat...

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Correlation of apparent diffusion coefficient and computed tomography density in acute ischemic stroke.

BACKGROUND AND PURPOSE Diffusion-weighted MR imaging is very sensitive for the detection of restricted molecular water diffusion in acute ischemic stroke. CT is sensitive to net water uptake in ischemic edema. We compared the decrease in the apparent diffusion coefficient (ADC) in diffusion-weighted MR imaging with CT density changes to study the correlation between diffusion restriction and wa...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2010

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1004841107